Zinc Finger Transcription Factors in Skeletal Development
نویسندگان
چکیده
منابع مشابه
Bernhard Ganss and Andrew Jheon Zinc Finger Transcription Factors in Skeletal Development
Cellular and molecular processes that regulate the development of skeletal tissues resemble those required for regeneration. Given the prevalence of degenerative skeletal disorders in an increasingly aging population, the molecular mechanisms of skeletal development must be understood in detail if novel strategies are to be developed in regenerative medicine. Research in this area over the past...
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The majority of human genes are conserved among mammals, but some gene families have undergone extensive expansion in particular lineages. Here, we present an evolutionary analysis of one such gene family, the poly-zinc-finger (poly-ZF) genes. The human genome encodes approximately 700 members of the poly-ZF family of putative transcriptional repressors, many of which have associated KRAB, SCAN...
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The ability to direct human telomerase reverse transcriptase (hTERT) expression through either genetic control or tunable regulatory factors would advance not only our understanding of the transcriptional regulation of this gene, but also potentially produce new strategies for addressing telomerase-associated disease. In this work, we describe the engineering of artificial zinc finger transcrip...
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ژورنال
عنوان ژورنال: Critical Reviews in Oral Biology & Medicine
سال: 2004
ISSN: 1045-4411,1544-1113
DOI: 10.1177/154411130401500504